Clinical Characteristics of Children with Coronavirus Disease 2019 in Hubei, China.
Identifieur interne : 000A32 ( Main/Exploration ); précédent : 000A31; suivant : 000A33Clinical Characteristics of Children with Coronavirus Disease 2019 in Hubei, China.
Auteurs : Fang Zheng [République populaire de Chine] ; Chun Liao [République populaire de Chine] ; Qi-Hong Fan [République populaire de Chine] ; Hong-Bo Chen [République populaire de Chine] ; Xue-Gong Zhao [République populaire de Chine] ; Zhong-Guo Xie [République populaire de Chine] ; Xi-Lin Li [République populaire de Chine] ; Chun-Xi Chen [République populaire de Chine] ; Xiao-Xia Lu [République populaire de Chine] ; Zhi-Sheng Liu [République populaire de Chine] ; Wei Lu [République populaire de Chine] ; Chun-Bao Chen [République populaire de Chine] ; Rong Jiao [République populaire de Chine] ; Ai-Ming Zhang [République populaire de Chine] ; Jin-Tang Wang [République populaire de Chine] ; Xi-Wei Ding [République populaire de Chine] ; Yao-Guang Zeng [République populaire de Chine] ; Li-Ping Cheng [République populaire de Chine] ; Qing-Feng Huang [République populaire de Chine] ; Jiang Wu [République populaire de Chine] ; Xi-Chang Luo [République populaire de Chine] ; Zhu-Jun Wang [République populaire de Chine] ; Yan-Yan Zhong [République populaire de Chine] ; Yan Bai [République populaire de Chine] ; Xiao-Yan Wu [République populaire de Chine] ; Run-Ming Jin [République populaire de Chine]Source :
- Current medical science [ 2523-899X ] ; 2020.
Abstract
Since December 2019, COVID-19 has occurred unexpectedly and emerged as a health problem worldwide. Despite the rapidly increasing number of cases in subsequent weeks, the clinical characteristics of pediatric cases are rarely described. A cross-sectional multicenter study was carried out in 10 hospitals across Hubei province. A total of 25 confirmed pediatric cases of COVID-19 were collected. The demographic data, epidemiological history, underlying diseases, clinical manifestations, laboratory and radiological data, treatments, and outcomes were analyzed. Of 25 hospitalized patients with COVID-19, the boy to girl ratio was 1.27:1. The median age was 3 years. COVID-19 cases in children aged <3 years, 3.6 years, and ≥6-years patients were 10 (40%), 6 (24%), and 9 (36%), respectively. The most common symptoms at onset of illness were fever (13 [52%]), and dry cough (11 [44%]). Chest CT images showed essential normal in 8 cases (33.3%), unilateral involvement of lungs in 5 cases (20.8%), and bilateral involvement in 11 cases (45.8%). Clinical diagnoses included upper respiratory tract infection (n=8), mild pneumonia (n=15), and critical cases (n=2). Two critical cases (8%) were given invasive mechanical ventilation, corticosteroids, and immunoglobulin. The symptoms in 24 (96%) of 25 patients were alleviated and one patient had been discharged. It was concluded that children were susceptible to COVID-19 like adults, while the clinical presentations and outcomes were more favorable in children. However, children less than 3 years old accounted for majority cases and critical cases lied in this age group, which demanded extra attentions during home caring and hospitalization treatment.
DOI: 10.1007/s11596-020-2172-6
PubMed: 32207032
Affiliations:
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Huazhong University of Science and Technology, Wuhan, 430022, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022</wicri:regionArea><wicri:noRegion>430022</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Xue Gong" sort="Zhao, Xue Gong" uniqKey="Zhao X" first="Xue-Gong" last="Zhao">Xue-Gong Zhao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Yichang No. 3 People's Hospital, Yichang, 443000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatrics, Yichang No. 3 People's Hospital, Yichang, 443000</wicri:regionArea><wicri:noRegion>443000</wicri:noRegion></affiliation></author><author><name sortKey="Xie, Zhong Guo" sort="Xie, Zhong Guo" uniqKey="Xie Z" first="Zhong-Guo" last="Xie">Zhong-Guo Xie</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Jingzhou First People's Hospital, Jingzhou, 434000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatrics, Jingzhou First People's Hospital, Jingzhou, 434000</wicri:regionArea><wicri:noRegion>434000</wicri:noRegion></affiliation></author><author><name sortKey="Li, Xi Lin" sort="Li, Xi Lin" uniqKey="Li X" first="Xi-Lin" last="Li">Xi-Lin Li</name><affiliation wicri:level="1"><nlm:affiliation>Xishui People's Hospital, Huanggang, 438000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Xishui People's Hospital, Huanggang, 438000</wicri:regionArea><wicri:noRegion>438000</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Chun Xi" sort="Chen, Chun Xi" uniqKey="Chen C" first="Chun-Xi" last="Chen">Chun-Xi Chen</name><affiliation wicri:level="1"><nlm:affiliation>Xishui People's Hospital, Huanggang, 438000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Xishui People's Hospital, Huanggang, 438000</wicri:regionArea><wicri:noRegion>438000</wicri:noRegion></affiliation></author><author><name sortKey="Lu, Xiao Xia" sort="Lu, Xiao Xia" uniqKey="Lu X" first="Xiao-Xia" last="Lu">Xiao-Xia Lu</name><affiliation wicri:level="1"><nlm:affiliation>Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430015, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430015</wicri:regionArea><wicri:noRegion>430015</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Zhi Sheng" sort="Liu, Zhi Sheng" uniqKey="Liu Z" first="Zhi-Sheng" last="Liu">Zhi-Sheng Liu</name><affiliation wicri:level="1"><nlm:affiliation>Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430015, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430015</wicri:regionArea><wicri:noRegion>430015</wicri:noRegion></affiliation></author><author><name sortKey="Lu, Wei" sort="Lu, Wei" uniqKey="Lu W" first="Wei" last="Lu">Wei Lu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Yichang Central Hospital, Yichang, 443000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatrics, Yichang Central Hospital, Yichang, 443000</wicri:regionArea><wicri:noRegion>443000</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Chun Bao" sort="Chen, Chun Bao" uniqKey="Chen C" first="Chun-Bao" 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first="Xi-Wei" last="Ding">Xi-Wei Ding</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Shiyan People's Hospital, Shiyan, 442000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatrics, Shiyan People's Hospital, Shiyan, 442000</wicri:regionArea><wicri:noRegion>442000</wicri:noRegion></affiliation></author><author><name sortKey="Zeng, Yao Guang" sort="Zeng, Yao Guang" uniqKey="Zeng Y" first="Yao-Guang" last="Zeng">Yao-Guang Zeng</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Huanggang Central Hospital, Huanggang, 438000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatrics, Huanggang Central Hospital, Huanggang, 438000</wicri:regionArea><wicri:noRegion>438000</wicri:noRegion></affiliation></author><author><name sortKey="Cheng, Li Ping" sort="Cheng, Li Ping" uniqKey="Cheng L" first="Li-Ping" last="Cheng">Li-Ping Cheng</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Huanggang Central Hospital, Huanggang, 438000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatrics, Huanggang Central Hospital, Huanggang, 438000</wicri:regionArea><wicri:noRegion>438000</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Qing Feng" sort="Huang, Qing Feng" uniqKey="Huang Q" first="Qing-Feng" last="Huang">Qing-Feng Huang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Jiangling People's Hospital, Jingzhou, 434101, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatrics, Jiangling People's Hospital, Jingzhou, 434101</wicri:regionArea><wicri:noRegion>434101</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Jiang" sort="Wu, Jiang" uniqKey="Wu J" first="Jiang" last="Wu">Jiang Wu</name><affiliation wicri:level="1"><nlm:affiliation>Huangshi Maternity and Child Health Care Hospital, Huangshi, 435000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Huangshi Maternity and Child Health Care Hospital, Huangshi, 435000</wicri:regionArea><wicri:noRegion>435000</wicri:noRegion></affiliation></author><author><name sortKey="Luo, Xi Chang" sort="Luo, Xi Chang" uniqKey="Luo X" first="Xi-Chang" last="Luo">Xi-Chang Luo</name><affiliation wicri:level="1"><nlm:affiliation>Huangshi Maternity and Child Health Care Hospital, Huangshi, 435000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Huangshi Maternity and Child Health Care Hospital, Huangshi, 435000</wicri:regionArea><wicri:noRegion>435000</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Zhu Jun" sort="Wang, Zhu Jun" uniqKey="Wang Z" first="Zhu-Jun" 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430074</wicri:regionArea><wicri:noRegion>430074</wicri:noRegion></affiliation></author><author><name sortKey="Bai, Yan" sort="Bai, Yan" uniqKey="Bai Y" first="Yan" last="Bai">Yan Bai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. yanbaixh@hust.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022</wicri:regionArea><wicri:noRegion>430022</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Xiao Yan" sort="Wu, Xiao Yan" uniqKey="Wu X" first="Xiao-Yan" last="Wu">Xiao-Yan Wu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. xwu@hust.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022</wicri:regionArea><wicri:noRegion>430022</wicri:noRegion></affiliation></author><author><name sortKey="Jin, Run Ming" sort="Jin, Run Ming" uniqKey="Jin R" first="Run-Ming" last="Jin">Run-Ming Jin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. jinrunm@qq.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022</wicri:regionArea><wicri:noRegion>430022</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno 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xml:lang="en">Clinical Characteristics of Children with Coronavirus Disease 2019 in Hubei, China.</title><author><name sortKey="Zheng, Fang" sort="Zheng, Fang" uniqKey="Zheng F" first="Fang" last="Zheng">Fang Zheng</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022</wicri:regionArea><wicri:noRegion>430022</wicri:noRegion></affiliation></author><author><name sortKey="Liao, Chun" sort="Liao, Chun" uniqKey="Liao C" first="Chun" last="Liao">Chun Liao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Yichang No. 3 People's Hospital, Yichang, 443000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatrics, Yichang No. 3 People's Hospital, Yichang, 443000</wicri:regionArea><wicri:noRegion>443000</wicri:noRegion></affiliation></author><author><name sortKey="Fan, Qi Hong" sort="Fan, Qi Hong" uniqKey="Fan Q" first="Qi-Hong" last="Fan">Qi-Hong Fan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Jingzhou First People's Hospital, Jingzhou, 434000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatrics, Jingzhou First People's Hospital, Jingzhou, 434000</wicri:regionArea><wicri:noRegion>434000</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Hong Bo" sort="Chen, Hong Bo" uniqKey="Chen H" first="Hong-Bo" last="Chen">Hong-Bo Chen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022</wicri:regionArea><wicri:noRegion>430022</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Xue Gong" sort="Zhao, Xue Gong" uniqKey="Zhao X" first="Xue-Gong" last="Zhao">Xue-Gong Zhao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Yichang No. 3 People's Hospital, Yichang, 443000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatrics, Yichang No. 3 People's Hospital, Yichang, 443000</wicri:regionArea><wicri:noRegion>443000</wicri:noRegion></affiliation></author><author><name sortKey="Xie, Zhong Guo" sort="Xie, Zhong Guo" uniqKey="Xie Z" first="Zhong-Guo" last="Xie">Zhong-Guo Xie</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Jingzhou First People's Hospital, Jingzhou, 434000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatrics, Jingzhou First People's Hospital, Jingzhou, 434000</wicri:regionArea><wicri:noRegion>434000</wicri:noRegion></affiliation></author><author><name sortKey="Li, Xi Lin" sort="Li, Xi Lin" uniqKey="Li X" first="Xi-Lin" last="Li">Xi-Lin Li</name><affiliation wicri:level="1"><nlm:affiliation>Xishui People's Hospital, Huanggang, 438000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Xishui People's Hospital, Huanggang, 438000</wicri:regionArea><wicri:noRegion>438000</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Chun Xi" sort="Chen, Chun Xi" uniqKey="Chen C" first="Chun-Xi" last="Chen">Chun-Xi Chen</name><affiliation wicri:level="1"><nlm:affiliation>Xishui People's Hospital, Huanggang, 438000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Xishui People's Hospital, Huanggang, 438000</wicri:regionArea><wicri:noRegion>438000</wicri:noRegion></affiliation></author><author><name sortKey="Lu, Xiao Xia" sort="Lu, Xiao Xia" uniqKey="Lu X" first="Xiao-Xia" last="Lu">Xiao-Xia Lu</name><affiliation wicri:level="1"><nlm:affiliation>Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430015, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430015</wicri:regionArea><wicri:noRegion>430015</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Zhi Sheng" sort="Liu, Zhi Sheng" uniqKey="Liu Z" first="Zhi-Sheng" last="Liu">Zhi-Sheng Liu</name><affiliation wicri:level="1"><nlm:affiliation>Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430015, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430015</wicri:regionArea><wicri:noRegion>430015</wicri:noRegion></affiliation></author><author><name sortKey="Lu, Wei" sort="Lu, Wei" uniqKey="Lu W" first="Wei" last="Lu">Wei Lu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Yichang Central Hospital, Yichang, 443000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatrics, Yichang Central Hospital, Yichang, 443000</wicri:regionArea><wicri:noRegion>443000</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Chun Bao" sort="Chen, Chun Bao" uniqKey="Chen C" first="Chun-Bao" last="Chen">Chun-Bao Chen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Yichang Central Hospital, Yichang, 443000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatrics, Yichang Central Hospital, Yichang, 443000</wicri:regionArea><wicri:noRegion>443000</wicri:noRegion></affiliation></author><author><name sortKey="Jiao, Rong" sort="Jiao, Rong" uniqKey="Jiao R" first="Rong" last="Jiao">Rong Jiao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Xiangyang First People's Hospital, Xiangyang, 441000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatrics, Xiangyang First People's Hospital, Xiangyang, 441000</wicri:regionArea><wicri:noRegion>441000</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Ai Ming" sort="Zhang, Ai Ming" uniqKey="Zhang A" first="Ai-Ming" last="Zhang">Ai-Ming Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Xiangyang First People's Hospital, Xiangyang, 441000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatrics, Xiangyang First People's Hospital, Xiangyang, 441000</wicri:regionArea><wicri:noRegion>441000</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Jin Tang" sort="Wang, Jin Tang" uniqKey="Wang J" first="Jin-Tang" last="Wang">Jin-Tang Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Shiyan People's Hospital, Shiyan, 442000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatrics, Shiyan People's Hospital, Shiyan, 442000</wicri:regionArea><wicri:noRegion>442000</wicri:noRegion></affiliation></author><author><name sortKey="Ding, Xi Wei" sort="Ding, Xi Wei" uniqKey="Ding X" first="Xi-Wei" last="Ding">Xi-Wei Ding</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Shiyan People's Hospital, Shiyan, 442000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatrics, Shiyan People's Hospital, Shiyan, 442000</wicri:regionArea><wicri:noRegion>442000</wicri:noRegion></affiliation></author><author><name sortKey="Zeng, Yao Guang" sort="Zeng, Yao Guang" uniqKey="Zeng Y" first="Yao-Guang" last="Zeng">Yao-Guang Zeng</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Huanggang Central Hospital, Huanggang, 438000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatrics, Huanggang Central Hospital, Huanggang, 438000</wicri:regionArea><wicri:noRegion>438000</wicri:noRegion></affiliation></author><author><name sortKey="Cheng, Li Ping" sort="Cheng, Li Ping" uniqKey="Cheng L" first="Li-Ping" last="Cheng">Li-Ping Cheng</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Huanggang Central Hospital, Huanggang, 438000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatrics, Huanggang Central Hospital, Huanggang, 438000</wicri:regionArea><wicri:noRegion>438000</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Qing Feng" sort="Huang, Qing Feng" uniqKey="Huang Q" first="Qing-Feng" last="Huang">Qing-Feng Huang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Jiangling People's Hospital, Jingzhou, 434101, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatrics, Jiangling People's Hospital, Jingzhou, 434101</wicri:regionArea><wicri:noRegion>434101</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Jiang" sort="Wu, Jiang" uniqKey="Wu J" first="Jiang" last="Wu">Jiang Wu</name><affiliation wicri:level="1"><nlm:affiliation>Huangshi Maternity and Child Health Care Hospital, Huangshi, 435000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Huangshi Maternity and Child Health Care Hospital, Huangshi, 435000</wicri:regionArea><wicri:noRegion>435000</wicri:noRegion></affiliation></author><author><name sortKey="Luo, Xi Chang" sort="Luo, Xi Chang" uniqKey="Luo X" first="Xi-Chang" last="Luo">Xi-Chang Luo</name><affiliation wicri:level="1"><nlm:affiliation>Huangshi Maternity and Child Health Care Hospital, Huangshi, 435000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Huangshi Maternity and Child Health Care Hospital, Huangshi, 435000</wicri:regionArea><wicri:noRegion>435000</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Zhu Jun" sort="Wang, Zhu Jun" uniqKey="Wang Z" first="Zhu-Jun" last="Wang">Zhu-Jun Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022</wicri:regionArea><wicri:noRegion>430022</wicri:noRegion></affiliation></author><author><name sortKey="Zhong, Yan Yan" sort="Zhong, Yan Yan" uniqKey="Zhong Y" first="Yan-Yan" last="Zhong">Yan-Yan Zhong</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Huazhong University of Science and Technology Hospital, Wuhan, 430074, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatrics, Huazhong University of Science and Technology Hospital, Wuhan, 430074</wicri:regionArea><wicri:noRegion>430074</wicri:noRegion></affiliation></author><author><name sortKey="Bai, Yan" sort="Bai, Yan" uniqKey="Bai Y" first="Yan" last="Bai">Yan Bai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. yanbaixh@hust.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022</wicri:regionArea><wicri:noRegion>430022</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Xiao Yan" sort="Wu, Xiao Yan" uniqKey="Wu X" first="Xiao-Yan" last="Wu">Xiao-Yan Wu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. xwu@hust.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022</wicri:regionArea><wicri:noRegion>430022</wicri:noRegion></affiliation></author><author><name sortKey="Jin, Run Ming" sort="Jin, Run Ming" uniqKey="Jin R" first="Run-Ming" last="Jin">Run-Ming Jin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. jinrunm@qq.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022</wicri:regionArea><wicri:noRegion>430022</wicri:noRegion></affiliation></author></analytic><series><title level="j">Current medical science</title><idno type="eISSN">2523-899X</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Since December 2019, COVID-19 has occurred unexpectedly and emerged as a health problem worldwide. Despite the rapidly increasing number of cases in subsequent weeks, the clinical characteristics of pediatric cases are rarely described. A cross-sectional multicenter study was carried out in 10 hospitals across Hubei province. A total of 25 confirmed pediatric cases of COVID-19 were collected. The demographic data, epidemiological history, underlying diseases, clinical manifestations, laboratory and radiological data, treatments, and outcomes were analyzed. Of 25 hospitalized patients with COVID-19, the boy to girl ratio was 1.27:1. The median age was 3 years. COVID-19 cases in children aged <3 years, 3.6 years, and ≥6-years patients were 10 (40%), 6 (24%), and 9 (36%), respectively. The most common symptoms at onset of illness were fever (13 [52%]), and dry cough (11 [44%]). Chest CT images showed essential normal in 8 cases (33.3%), unilateral involvement of lungs in 5 cases (20.8%), and bilateral involvement in 11 cases (45.8%). Clinical diagnoses included upper respiratory tract infection (n=8), mild pneumonia (n=15), and critical cases (n=2). Two critical cases (8%) were given invasive mechanical ventilation, corticosteroids, and immunoglobulin. The symptoms in 24 (96%) of 25 patients were alleviated and one patient had been discharged. It was concluded that children were susceptible to COVID-19 like adults, while the clinical presentations and outcomes were more favorable in children. However, children less than 3 years old accounted for majority cases and critical cases lied in this age group, which demanded extra attentions during home caring and hospitalization treatment.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zheng, Fang" sort="Zheng, Fang" uniqKey="Zheng F" first="Fang" last="Zheng">Fang Zheng</name></noRegion><name sortKey="Bai, Yan" sort="Bai, Yan" uniqKey="Bai Y" first="Yan" last="Bai">Yan Bai</name><name sortKey="Chen, Chun Bao" sort="Chen, Chun Bao" uniqKey="Chen C" first="Chun-Bao" last="Chen">Chun-Bao Chen</name><name sortKey="Chen, Chun Xi" sort="Chen, Chun Xi" uniqKey="Chen C" first="Chun-Xi" last="Chen">Chun-Xi Chen</name><name sortKey="Chen, Hong Bo" sort="Chen, Hong Bo" uniqKey="Chen H" first="Hong-Bo" last="Chen">Hong-Bo Chen</name><name sortKey="Cheng, Li Ping" sort="Cheng, Li Ping" uniqKey="Cheng L" first="Li-Ping" last="Cheng">Li-Ping Cheng</name><name sortKey="Ding, Xi Wei" sort="Ding, Xi Wei" uniqKey="Ding X" first="Xi-Wei" last="Ding">Xi-Wei Ding</name><name sortKey="Fan, Qi Hong" sort="Fan, Qi Hong" uniqKey="Fan Q" first="Qi-Hong" last="Fan">Qi-Hong Fan</name><name sortKey="Huang, Qing Feng" sort="Huang, Qing Feng" uniqKey="Huang Q" first="Qing-Feng" last="Huang">Qing-Feng Huang</name><name sortKey="Jiao, Rong" sort="Jiao, Rong" uniqKey="Jiao R" first="Rong" last="Jiao">Rong Jiao</name><name sortKey="Jin, Run Ming" sort="Jin, Run Ming" uniqKey="Jin R" first="Run-Ming" last="Jin">Run-Ming Jin</name><name sortKey="Li, Xi Lin" sort="Li, Xi Lin" uniqKey="Li X" first="Xi-Lin" last="Li">Xi-Lin Li</name><name sortKey="Liao, Chun" sort="Liao, Chun" uniqKey="Liao C" first="Chun" last="Liao">Chun Liao</name><name sortKey="Liu, Zhi Sheng" sort="Liu, Zhi Sheng" uniqKey="Liu Z" first="Zhi-Sheng" last="Liu">Zhi-Sheng Liu</name><name sortKey="Lu, Wei" sort="Lu, Wei" uniqKey="Lu W" first="Wei" last="Lu">Wei Lu</name><name sortKey="Lu, Xiao Xia" sort="Lu, Xiao Xia" uniqKey="Lu X" first="Xiao-Xia" last="Lu">Xiao-Xia Lu</name><name sortKey="Luo, Xi Chang" sort="Luo, Xi Chang" uniqKey="Luo X" first="Xi-Chang" last="Luo">Xi-Chang Luo</name><name sortKey="Wang, Jin Tang" sort="Wang, Jin Tang" uniqKey="Wang J" first="Jin-Tang" last="Wang">Jin-Tang Wang</name><name sortKey="Wang, Zhu Jun" sort="Wang, Zhu Jun" uniqKey="Wang Z" first="Zhu-Jun" last="Wang">Zhu-Jun Wang</name><name sortKey="Wu, Jiang" sort="Wu, Jiang" uniqKey="Wu J" first="Jiang" last="Wu">Jiang Wu</name><name sortKey="Wu, Xiao Yan" sort="Wu, Xiao Yan" uniqKey="Wu X" first="Xiao-Yan" last="Wu">Xiao-Yan Wu</name><name sortKey="Xie, Zhong Guo" sort="Xie, Zhong Guo" uniqKey="Xie Z" first="Zhong-Guo" last="Xie">Zhong-Guo Xie</name><name sortKey="Zeng, Yao Guang" sort="Zeng, Yao Guang" uniqKey="Zeng Y" first="Yao-Guang" last="Zeng">Yao-Guang Zeng</name><name sortKey="Zhang, Ai Ming" sort="Zhang, Ai Ming" uniqKey="Zhang A" first="Ai-Ming" last="Zhang">Ai-Ming Zhang</name><name sortKey="Zhao, Xue Gong" sort="Zhao, Xue Gong" uniqKey="Zhao X" first="Xue-Gong" last="Zhao">Xue-Gong Zhao</name><name sortKey="Zhong, Yan Yan" sort="Zhong, Yan Yan" uniqKey="Zhong Y" first="Yan-Yan" last="Zhong">Yan-Yan Zhong</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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